Asymmetric synthesis of CF₂-functionalized aziridines by combined strong Brønsted acid catalysis

• Xing-Fa Tan,
• Fa-Guang Zhang and
• Jun-An Ma

Beilstein J. Org. Chem. 2020, 16, 638–644, doi:10.3762/bjoc.16.60

• . Scale-up experiment to 4a and further synthetic transformations. Representative screening results of the asymmetric aziridination reaction of PhSO2CF2CHN2.a Supporting Information Supporting Information File 244: Experimental procedures, compound characterization, NMR spectra of all new compounds, and

Synthesis of chiral N-phosphoryl aziridines through enantioselective aziridination of alkenes with phosphoryl azide via Co(II)-based metalloradical catalysis

• Jingran Tao,
• Li-Mei Jin and
• X. Peter Zhang

Beilstein J. Org. Chem. 2014, 10, 1282–1289, doi:10.3762/bjoc.10.129

• Jingran Tao Li-Mei Jin X. Peter Zhang Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA 10.3762/bjoc.10.129 Abstract The Co(II) complex of a new D2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis

• 85% ee). In addition to mild reaction conditions and generation of N2 as the only byproduct, this new metalloradical catalytic system is highlighted with a practical protocol that operates under neutral and non-oxidative conditions. Keywords: asymmetric aziridination; aziridine; chiral porphyrin

• aryl azides have been effectively employed for metal-catalyzed asymmetric aziridination [16][17][18][19], the catalytic system based on other types of azides, such as phosphoryl azides, remains underdeveloped. Phosphoryl azides, a family of common organic azides that can be directly synthesized from